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. 2013 May 22;3:125. doi: 10.3389/fonc.2013.00125

Figure 2.

Figure 2

Domain organization of the PML and the PML-RARα proteins. (A) The domains, the motifs, and their amino acid (aa) positions relative to the PMLI isoform are presented. These include the RBCC/TRIM, the NLS, the NES, and the SIM hydrophobic core (VVVI) motifs as well as the adjacent sequences containing the CK2-phosphorylation sites. The three major (K65, K160, and K490) and five minor (K226, 380, 400, 497, 616) SUMOylation sites are shown. A bracket indicates the common region shared by PMLI to PMLV and encoded by exons 1 to 7a. The SIM encoded by exon 7a is missing in PMLVI and PMLVIIb. The K616 encoded by exon 8a is found only in PMLI and PMLIV. The NES is present only in PMLI. (B) The short and the long PML-RARα fusion proteins and their translocation breakpoints are shown.