Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Role of CK2 phosphorylated serines and the VVVI hydrophobic core in PML degradation. In response to osmotic shock, anisomycin, or UV radiation, PML is phosphorylated at the CK2 serine sites (red) adjacent to the SIM hydrophobic core (VVVI) (blue) leading to PML degradation. In contrast, As2O3-induced PML degradation requires the SIM VVVI.
