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. Author manuscript; available in PMC: 2013 May 22.
Published in final edited form as: Nat Rev Microbiol. 2012 Oct;10(10):693–704. doi: 10.1038/nrmicro2875

Figure 3. The fungal Hsp90 chaperone machine and exemplar client proteins.

Figure 3

The shape of the Hsp90 machine is adapted from Pearl et al. (2008)26, illustrating the amino- (N), middle (M) and carboxy-terminal (C) domains. The specificity of an Hsp90 complex depends on which co-chaperone it binds. Co-chaperones can bind different faces of Hsp90. Examples of Hsp90 client proteins that are representative of the major cellular processes that Hsp90 influences are illustrated in blue.