Table II. Characteristics at Onset of Toxicity.
| Data | Units | Pt 1 | Pt 2 | Pt 3 | Pt 4 | Pt 5 |
|---|---|---|---|---|---|---|
| Time from Diagnosis | Days | 6 | 41 (5 days from disease reactivation) | 42 | 5 | 25 |
| Duration of Cyclosporine Therapy | Days | 6 | 41 | 20 | 5 | 25 |
| Prodromal Symptoms | NA | AMS* | AMS, somnolence, delirium | Tremors, AMS, somnolence, decreased speech | AMS, somnolence, decreased speech | AMS, somnolence |
| Blood Pressure | mm Hg | 148/75 | 145/90 | 145/62 | 155/90 | 175/106 |
| Ferritin | ng/ml | 40,312 | 603 | 2,755 | 10,297 | 529 |
| AST/ALT | U/L | 808/315 | 459/132 | 27/31 | 848/165 | 42/40 |
| PT/PTT | sec | 14.9/31.8 | 21.2/64.8 | 13.8/34.1 | 15.0/32.1 | 13/20.7 |
| Serum Cr | mg/dl | 4.0 | 4.2 | 0.6 | 0.8 | 0.4 |
| Cyclosporine Trough | ng/dl | 532 | 384 | 204 | 269 | 224 |
*
AMS = Altered Mental Status