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. Author manuscript; available in PMC: 2013 May 22.
Published in final edited form as: Nucleosides Nucleotides Nucleic Acids. 2009 Feb;28(2):67–77. doi: 10.1080/15257770902736426

SCHEME 4.

SCHEME 4

Synthesis of a fully protected monomer that can be converted to the N2-dG adduct after oligonucleotide synthesis.

Reaction conditions: a. Pd(OAc)2, Cs2CO3, BINAP, toluene (88%); b. TBAF, THF (80%); c. DMT-Cl, DMAP, TEA, pyridine (80%); d. 2-Cyanoethyl-N,N-diisopropylchlorophosphoramidite, TEA, CH2Cl2, r.t., 1h (60%).