Figure 2. Sequence alignments of toxins and pore regions of K+ channels.
(A) Sequence alignments of five toxins belonging to the CTX family of K+ channel toxins. The conserved cysteines that form disulfide bonds are shown in blue and the conserved lysine that competes with K+ is shown in red. (B) Sequence alignment of the pore regions of selected members of the Shaker family of channels and KcsA–paddle chimera, rat Kv2.1 (GI:24418849), rat Kv1.2 (GI:1235594), human Kv1.1 (GI:119395748), human Kv 1.3 (GI:88758565), human Kv1.5 (GI:25952087), Shaker Kv (GI:13432103), and KcsA (GI:61226909). The sequence of the selectivity filter is shown in red.