Table 1.
Demographic data, clinical data, TCS results of study patients, and diagnostic accuracy of midbrain hyperechogenicity for the differential diagnosis of PD versus SWEDD
| Demographic and Clinical Data | PD Patients | SWEDD Patients | PD Versus SWEDD |
|---|---|---|---|
| Patients, n | 19 | 14 | |
| Female/male, n | 7:12 | 7:7 | 0.497 |
| Age, years (mean ± SD) | 63.3. ± 7.5 | 68.2 ± 10.8 | 0.130 |
| Age at onset, years (mean ± SD) | 55.4 ± 11.8 | 56.3 ± 11.8 | 0.830 |
| Disease duration, years (mean ± SD) | 7.5 ± 7.2 | 14.9 ± 11.3 | 0.030* |
| DAT-SPECT after disease onset, years (mean ± SD) | 7.2 ± 9.3 | 7.5 ± 7.9 | 0.900 |
| Sufficient bone window, n (%) | 17 (89.5) | 11 (78.5) | 0.630 |
| Midbrain hyperechogenicity, n (%) | 14 (82.5) | 1 (9.1) | <0.001* |
| UPDRS motor score, mean ± SD | 18 ± 10 | 10.8 ± 3.7 | 0.020* |
| Sensitivity, % | 82.4 (58.2–94.6) | ||
| Specificity, % | 90.9 (60.1–99.9) | ||
| PPV, % | 93.3 (68.2–99.9) | ||
| NPV, % | 76.9 (49.1–92.5) | ||
| Overall accuracy, % | 85.7 (67.9–94.9) | ||
| Likelihood ratio | 9.06 | ||
| TP, n | 14 | ||
| FP, n | 1 | ||
| FN, n | 3 | ||
| TN, n | 10 |
Data in parentheses are the confidence intervals.
*
Significance level: P < 0.05.
Abbreviations: TP, true positive; FP, false positive; FN, false negative; TN, true negative.