Distribution and clearance of control or PTPµ targeted contrast agents following intravenous administration in xenograft mice. Representative T
1-weighted longitudinal 3D maximum intensity projection images of mice bearing LN-229 flank tumors before (Pre) and at 1, 5, 10, 15, 20, 25, and 30 minutes after intravenous injection of ProHance, scrambled Tris-(Gd-DOTA)3, or SBK2-Tris-(Gd-DOTA)3 contrast agents at 0.1 mmol Gd/kg in nude mice [n = 4 for ProHance; n = 6 for both scrambled Tris-(Gd-DOTA)3 and SBK2-Tris-(Gd-DOTA)3]. Arrow indicates bladder localization.