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. 2013 May 21;19(19):2847–2863. doi: 10.3748/wjg.v19.i19.2847

Figure 1.

Figure 1

Chemokine-induced signal transduction pathways. Schematic representation of signaling pathways activated by binding of chemokine ligands to their seven transmembrane G-protein coupled receptors. MMPs: Matrix metalloproteinases; TFs: Transcription factors; RTK: Receptor tyrosine kinase; ERK: Extracellular signal-regulated kinase; MEK: Mitogen-activated protein/extracellular signal-regulated kinase kinase; PI-3K: Phosphatidyl inositide-3-OH kinase; MKK: Mitogen-activated protein kinase kinase; JNK: c-Jun N-terminal kinase; AKT: Protein kinase B.