Figure 2.
Effect of PHY906 on the weight of mice receiving fractionated whole-abdomen irradiation. Mice were randomized to receive whole abdomen irradiation (4 daily 2 Gy fractions, days 1-4) alone or in combination with PHY906 treatment (~8:30 AM and ~4PM daily by oral gavage; 500 mg/kg/dose) for 4 days. Mice received one 4-day course of PHY906 or two 4-day courses of PHY906 separated by a 3-day interval. Crosshatched box: radiation and PHY906. Single hatched box: second course of PHY906. The weight for each mouse was normalized to the pretreatment weight of that animal. Data are means ± SEM from three replicate experiments, each with 6 mice per group.