. Author manuscript; available in PMC: 2013 May 22.

Published in final edited form as: Int J Radiat Biol. 2012 Sep 3;89(1):16–25. doi: 10.3109/09553002.2012.717733

Table I.

Effect of PHY906 on tumor growth delays induced by irradiation in four independent experiments. Tumors were inoculated, randomized and treated with irradiation alone or in combination with PH906. The times for the tumors in each group to grow from the volume at the time of randomization to 4 times that volume are shown, with their SEM

Radiation Regimen	Time to 4X
Radiation Regimen	Control	Sham	PHY906 only	X-ray Only	PHY906 + X-ray
10 Gy	22.4 ± 1.1	21.8 ± 0.9	21.0 ± 1.4	27.4 ± 1.1^*	29.0 ± 1.2^*
10 Gy	13.5 ± 1.4	11.3 ± 0.6	13.6 ± 1.3	21.0 ± 1.1^*	20.8 ± 0.9^*
4 X 2.5 Gy	3.8 ± 0.8			18.3 ± 1.4^*	19.4 ± 1.3^*
4 X 2.5 Gy	15.6 ± 1.4			18.4 ± 1.0	20.0 ± 0.7^*

Significantly different from control (p <0.05). PHY906 did not produce statistically significant changes in the time to 4X for either unirradiated or irradiated tumors (p.>0.05). The tumor growth curves for a representative experiment (row 3) are shown on Figure 6; tumor growth curves for other experiments are not show.