FIG. 1.

Electrically evoked auditory brainstem response (EABR) threshold data. A Longitudinal EABR thresholds are shown for the two stimulated channels of the cochlear implant (solid lines, apical bipolar electrode pair 1,2; dashed lines, basal electrodes 5, 6) recorded in neonatally deafened animals during 10 weeks of intracochlear BDNF infusion and several months of chronic electrical stimulation. B Longitudinal EABR data for the non-stimulated control channel (electrodes 3, 4) in the five BDNF + ES animals. C EABR thresholds for the two stimulated channels in the ES-only animals. D Mean summary data show a significant improvement in threshold (initial vs. final threshold) on the stimulated channels in the BDNF + ES group. In contrast, no significant change over time is seen for the unstimulated middle channel (3,4) of the BDNF + ES group or for the stimulated channels of the ES-only group. (Data shown are means and standard deviations; ***p < 0.001.)