TABLE 1.

Detailed experimental histories and SG numerical density data are shown for individual cats in the BDNF + ES and ES-only groups for which histological data are presented

Subject	No. of days (neomycin)	Age at implant (weeks)	Age at Stimulation (weeks)	Type of stimulation	Duration of stimulation (weeks)	Age at study (weeks)	SG density (% normal)
							Implant	Contralateral
Neonatally deafened cats: BDNF infusion and ES
#1–K313	16	5	10	SPa	14	24	75 %	50 %
#2–K318	16	5	8	SPa	17	25	76 %	43 %
#3–K319b	16	5	8	SPa	21	29	57 %	37 %
#4–K324	15	4.5	7	SPa	26	33	55 %	40 %
#5–K329	21	4	7	300 pps/30 Hzc	22.5	30	88 %	56 %
Mean (n = 5)	17	5	8		20	28.2	70 %	45 %
Neonatally deafened cats: ES-only controls
#1–K352	16	6	8	SPa	15.5	24	69 %	56 %
#2–K335	16	7	9	SPa	16.5	26	78 %	57 %
#3–K83	19	9	10	80 pps	22	32	66 %	45 %
#4–K101	18	9	8	300 pps/30 Hzc	29	37	50 %	34 %
#5–K89	19	9	10	300 pps/30 Hzc	22	31	53 %	43 %
Mean (n = 5)	18	8	9		21	30	63 %	47 %

All animals received electrical stimulation simultaneously on two bipolar channels of the cochlear implant (see text). Two subjects in the ES-only control group (K352, K335) were implanted and stimulated concurrently with the BDNF + ES group. The remaining three subjects were selected from a previous study to match as closely as possible the type and duration of stimulation and age at study of the subjects in the BDNF + ES group. The subjects in the ES-only group are listed in the same order as the subjects they were selected to match in the BDNF + ES group

^aSP, chronic stimulation was delivered by two channels of a CII™ Speech Processor (see text)

^bIn subject K319, electrode wire #5 failed 1 month after implantation, and stimulation was subsequently delivered on electrodes #4 and #6

^c300 pps/30 Hz, chronic stimulation was a continuous train of biphasic pulses (200 μs/phase) delivered at 300 pps and 100 % sinusoidally amplitude modulated at 30 Hz