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B[a]P-7,8-dione-dAde adducts detected from HBEC-KT cells. (A) MS3 chromatogram at 0 h. (B) MS3 chromatogram at 24 h. (C) MS3 spectrum at 18.06 min. HBEC-KT cells (∼5 × 106) were treated with B[a]P-7,8-dione (2 μM, 0.2% (v/v) DMSO) in HBSS buffer containing 1 mM sodium pyruvate. The cell pellets were collected at 0 and 24 h. The DNA from cell pellets was extracted and subsequently hydrolyzed before analysis on an ion trap LC-MS/MS.
