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. 2013 May 22;7:64. doi: 10.3389/fncom.2013.00064

Figure 4.

Figure 4

Effect of MF-GrC synaptic weight on GrC activity. In these simulations the following weight configuration was used: MF-GrC AMPA receptor 0–1.74 nS (NMDA-receptor weight has been proportionally set), MF-GoC 1 nS, GrC-GoC 3 nS, GoC-GrC 1.5 nS, SC-GoC 0 nS, and GoC-GoC 0 nS. (A) GrC response with three different MF-GrC weights (reported for AMPA): LTD (0.61 nS; green), Control (0.87 nS; red) and LTP (1.13 nS; blue). The theoretical distribution of the MF stimulation burst is shown with a dashed line. (Top) Membrane potential in a single GrC and its firing threshold (dotted straight line at −40 mV). (Middle) E/I g balance of the GrC population with the three MF-GrC weight settings. (Bottom) PSTH of the GrC response after the first spike in the burst. Note that LTP produces greater and earlier responses, while the opposite occurs with LTD. These changes in the PSTH are consistent with those in the E/I g balance. (B) Plots of the average input/output offset (top) and of the GrC firing probability (bottom) with respect to MF-GrC weights. (C) Relative number of GrCs generating zero, one, two, or three spikes in response to the stimulation burst.