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. 2013 May 22;7:64. doi: 10.3389/fncom.2013.00064

Figure 9.

Figure 9

Effect of SC-GoC synaptic weight on GrC activity. In these simulations the following weight configuration was used: MF-GrC 0.61 nS (LTD), 0.87 nS (control), or 1.13 nS (LTP) (AMPA-receptor weight), MF-GoC 1 nS, GrC-GoC 3 nS, GoC-GrC 1.5 nS, SC-GoC 0 nS (LTD/disabled, green), 0.25 nS (control, red), 1 nS (LTD, blue), GoC-GoC 0 nS. (A) GrC response with MF-GrC control configuration and three different SC-GoC configurations. The theoretical distribution of the MF stimulation burst is shown with a dashed line. (Top left corner) Membrane potential in a single GrC and its firing threshold (dotted straight line at −40 mV). (Bottom Left) E/I g balance of the GrC population. (Top right corner) PSTH of the GrC response after the first spike in the burst. SC-GoC did not influence the GrC responsiveness during the initial part of the burst in MF-GrC control conditions. (B) Relative number of GrCs generating zero, one, two, or three spikes in response to the stimulation burst. These are reported for three different MF-GrC configurations. Similarly to the GoC-GoC connection reported in Figure 8, SC-GoC LTP configuration noticeably enhanced the proportion of GrCs that fire doublets in MF-GrC control and LTP.