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. Author manuscript; available in PMC: 2013 May 22.
Published in final edited form as: Endocr Relat Cancer. 2012 Oct 30;19(6):C33–C40. doi: 10.1530/ERC-12-0118

Figure 2.

Figure 2

Methylation of histones like trimethylated lysine 27 on histone H3 (H3K27me3) controls transcription by allowing chromosomal regions to alternate between ‘on’ and ‘off’. Jumonji domain-containing 3 (JMJD3) belongs to a family of enzymes that uses a Jumonji C (JmjC) domain to catalyze demethylation on lysines. In cells with inactivated SDHB, increased methylation of histone H3 can be reversed by overexpression of the JMJD3, indicating that histone demethylases may be involved in the formation of paragangliomas (and related tumors).