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. Author manuscript; available in PMC: 2013 May 22.
Published in final edited form as: Acta Pharm Sin B. 2012 Aug;2(4):341–349. doi: 10.1016/j.apsb.2012.06.010

Table 1.

Mitochondrial inhibitors and their function.

Mitochondrial inhibitor Function
Berberine Inhibit mitochondrial respiration
Metformin Inhibit mitochondrial respiration, uncoupling oxidative phosphorylation
TZDs Inhibit respiratory chain complex I
Resveratrol Inhibit mitochondrial ATP synthase
Piceatannol Inhibit ATPase activity of mitochondrial ATP synthase
Diethylstilbestrol (DES) Inhibit proton translocation activities of mitochondria
Quercetin Inhibit ATPase activity of mitochondria
Genistein Inhibit ATP hydrolysis and ATP synthesis activities of mitochondrial ATP synthase
Biochanin A Inhibit ATPase activity of mitochondria
Epicatechin gallate (ECG) Epigallocatechin gallate (EGCG) Inhibit ATP hydrolysis activity of ATP synthase
Curcumin Inhibit ATPase activity of mitochondria
Phloretin, theaflavin, tannic acid Inhibit ATPase activity of mitochondria
Estrogen Inhibit ATPase activity of mitochondria
Oligomycin Inhibit ATP synthase
Ossamycin Inhibit both ATPase and oxidative phosphorylation activities of mitochondrial ATP synthase
Propranolol Inhibit mitochondrial ATPase activity
Atrazine Inhibit ATP synthesis activity of ATP synthase
Azide Inhibit ATPase activity of mitochondria