Table 1.
Effects of calcium alone and calcium plus gadolinium at different concentrations on proliferation of HCT-116 cells and SW480 cells
| Conditions | Number of cells ×10−4 | |
|---|---|---|
| HCT-116 | SW480 | |
| 1.5 mM calcium | 13.2±0.1 | 14.4±0.2 |
| 3.0 mM calcium | 9.9±0.1 | 9.8±0.2 |
| +1 µM Gd3+ | 9.3±0.2 | 9.6±0.1 |
| +5 µM Gd3+ | 7.5±0.3* | 8.2±0.1* |
| +10 µM Gd3+ | 4.0±0.1* | 7.9±0.3* |
| +25 µM Gd3+ | 1.3±0.1* | 3.9±0.1* |
| +50 µM Gd3+ | 0.8±0.1* | 1.9±0.2* |
| 4.5 mM calcium | 6.1±0.2 | 6.4±0.1 |
| +1 µM Gd3+ | 6.0±0.1 | 6.0±0.3 |
| +5 µM Gd3+ | 5.4±0.4* | 5.9±0.2 |
| +10 µM Gd3+ | 4.8±0.1* | 5.9±0.1 |
| +25 µM Gd3+ | 2.0±0.2* | 4.0±0.2* |
| +50 µM Gd3+ | 1.7±0.1* | 2.6±0.4* |
Values shown are means and standard deviations based on a single experiment with three samples per data point for each condition. Statistical significance of the data was assessed by ANOVA, followed by paired-group comparisons. The experiment was repeated three times with similar results
p<0.05 (statistically significant decrease relative to controls)