Table 2.

Systemic exposure (AUC_0–8) of atorvastatin acid, effect of time, surgical procedure, and body mass index (BMI)

	Crude model		Adjusted model
Explanatory variable	Estimate (95 % CI)	p value	Estimate (95 % CI)	p value
Time	−0.018 (−0.028 to −0.008)	0.001	−0.024 (−0.046 to −0.001)	0.048
Surgical procedure			0.418 (−0.289 to 1.125)	0.260
Surgical procedure × time			−0.013 (−0.034 to 0.007)	0.221
BMI			−0.021 (−0.055 to 0.013)	0.239

Linear mixed model analysis

CI confidence interval, AUC _0–8 area under the plasma concentration versus the time curve from 0 to 8 h postdose