Table 3.
Cumulative toxicities assesseda (N = 22)
| Toxicity Grade |
|||||
|---|---|---|---|---|---|
| Toxicity term | 1 | 2 | 3 | 4 | 5 |
| Nausea | 11 | 2 | |||
| Vomiting | 8 | 2 | 1 | ||
| Fatigue | 7 | 1 | |||
| Headache | 4 | ||||
| Anorexia | 3 | 1 | |||
| Abdominal pain | 3 | ||||
| Pruritus | 3 | ||||
| Constipation | 2 | 1 | |||
| Lymphopenia | 1 | 1 | 1 | ||
| Ataxia | 1 | 1 | |||
| Rash | 1 | 1 | |||
| Extrapyramidal/involuntary movement | 2 | ||||
| Hemiparesis | 2 | ||||
| Neurology–motor (gait) | 1 | 1 | |||
| Neutropenia | 1 (DLT) | ||||
| Alopecia | 1 | ||||
| Cushingoid appearance | 1 | ||||
| Fever | 1 | ||||
| Striae | 1 | ||||
| Diarrhea | 1 | ||||
| Infection | 1 | ||||
| Tinnitus | 1 | ||||
| Tachypnea | 1 | ||||
| Insomnia | 1 | ||||
| Hypertension | 1 | ||||
| Mucositis | 1 | ||||
| Prolonged QTc | 1 | ||||
| Neuropathy–sensory | 1 | ||||
| Hypokalemia | 1 | ||||
| Hypomagnesemia | 1 | ||||
| Cough | 1 | ||||
| Allergic reaction | 1 | ||||
| Leukopenia | 1 | ||||
| Flushing | 1 | ||||
| Cardiac–other (T-wave abnormality) | 1 | ||||
aAccording to the Common Terminology Criteria for Adverse Events, version 3.0 for all findings with a possible, probably, or definite attribution to ATO administration in the 22 patients evaluable for toxicity.