Figure 2. (A) Average methylation levels for CpG sites analyzed in maternal (□) and fetal (•) sides of the placenta for leptin gene promoter (n = 47). In (B), cord blood (Δ) (n = 39) and maternal (□) and fetal (•) placental tissues (n = 97) average cytosine methylation for adiponectin gene CpG island C1 and E2. Spearman correlation between methylation of CpG sites in maternal and fetal tissues and cord blood: *p ≤ 0.05 and **p ≤ 0.01. CpG sites analyzed were the same as previously described.^16,17