Figure 1. DEC-205 facilitates the uptake of CpG oligodeoxynucleotides. (A) A CD8⁺ DC bearing intracellular CpG oligodeoxynucleotides (ODN) upon DEC-205-mediated internalization. Nuclei appear in blue, MHC Class II molecules in green and a fluorescent CpG ODN in red. Yellow zones constitute areas in which CpG ODN has co-localized with MHC Class II molecules. (B) Role of DEC-205 in the capture and internalization of CpG ODNs by CD8⁺ DCs.