Table 1. Activating ligands for human Vδ2 and non-Vδ2 γδ T cells expressed by tumor cells: a simplified view.
|
Ligands for |
|||
---|---|---|---|---|
γδ T cell subset | T-cell receptor | NKGD2 | NKp30 | |
|
Vδ2 |
IPP, hMSH2 |
MICA, ULBP1 |
|
non-Vδ2: | Vδ1 |
unknown, MICA |
ULBP3 |
B7-H659 |
Vδ5 | EPCR | n.d. |
EPCR, endothelial protein C receptor; hMSH2, human MutS homologue 2; IPP, isopentenyl pyrophosphate; MICA, MHC Class I-related chain A; n.d., not determined; ULBP, UL16-binding protein.