Table 1.

Changes in steroids from baseline to three months

SUB PATHWAY	BIOCHEMICAL NAME	Fold of change, Month 3 vs. Baseline	p-value for paired t-test, Month 3 vs. Baseline	q-value for paired t-test, Month 3 vs. Baseline
Sterol/Steroid	cholesterol	1.06	0.029	0.120
	dehydroisoandrosterone sulfate (DHEA-S)	0.87	< 0.001	0.002
	epiandrosterone sulfate	0.50	< 0.001	<0.001
	androsterone sulfate	0.50	< 0.001	<0.001
	cortisol	0.84	0.012	0.072
	cortisone	0.89	0.369	0.370
	7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca)	1.01	0.653	0.478
	4-androsten-3beta,17beta-diol disulfate 1	0.87	< 0.001	0.003
	4-androsten-3beta,17beta-diol disulfate 2	0.70	< 0.001	<0.001
	5alpha-androstan-3beta,17beta-diol disulfate	0.33	< 0.001	<0.001
	pregnen-diol disulfate	0.76	< 0.001	<0.001
	pregn steroid monosulfate	0.76	< 0.001	<0.001
	andro steroid monosulfate 1	0.88	0.029	0.120
	andro steroid monosulfate 2	0.93	0.321	0.356

• All values are normalized in terms of raw area counts.

• “Fold change Month 3 vs. Baseline” denotes <month 3 level> divided by <baseline level> of each biochemical (i.e. fold change of 0.76 denotes a 24% decrease).

• Shading corresponds to degree of change. Thresholds for color intensity are as follows: green denotes ≤ 0.65 fold change, dark green denotes 0.65 - 0.95 fold change, black denotes 0.95 – 1.05 fold change, dark red denotes 1.05 – 1.35 fold change, red denotes ≥ 1.35 fold change.