Table 2.
Changes in bile acids from baseline to three months
| SUB PATHWAY | BIOCHEMICAL NAME | Fold of change, Month 3 vs. Baseline | p-value for paired t-test, Month 3 vs. Baseline | q-value for paired t-test, Month 3 vs. Baseline |
|---|---|---|---|---|
| Bile acid metabolism | cholate | 1.94 | 0.023 | 0.107 |
| glycocholate | 1.27 | 0.976 | 0.553 | |
| taurocholate | 2.08 | 0.435 | 0.404 | |
| chenodeoxycholate | 1.19 | 0.189 | 0.310 | |
| taurochenodeoxycholate | 1.70 | 0.698 | 0.498 | |
| ursodeoxycholate | 1.57 | 0.088 | 0.222 | |
| hyodeoxycholate | 1.33 | 0.089 | 0.222 | |
| deoxycholate | 1.36 | 0.398 | 0.382 | |
| taurodeoxycholate | 1.21 | 0.311 | 0.356 | |
| glycodeoxycholate | 1.19 | 0.660 | 0.481 | |
| 7-ketodeoxycholate | 1.06 | 0.208 | 0.324 | |
| glycochenodeoxycholate | 1.48 | 0.136 | 0.269 | |
| glycolithocholate sulfate* | 1.12 | 0.634 | 0.468 | |
| taurolithocholate 3-sulfate | 1.16 | 0.982 | 0.554 | |
| glycocholenate sulfate* | 0.96 | 0.372 | 0.370 | |
| taurocholenate sulfate* | 0.85 | 0.128 | 0.266 |
• All values are normalized in terms of raw area counts.
• “Fold change Month 3 vs. Baseline” denotes <month 3 level> divided by <baseline level> of each biochemical (i.e. fold change of 0.76 denotes a 24% decrease).
• Shading corresponds to degree of change. Thresholds for color intensity are as follows: green denotes ≤ 0.65 fold change, dark green denotes 0.65 - 0.95 fold change, black denotes 0.95 – 1.05 fold change, dark red denotes 1.05 – 1.35 fold change, red denotes ≥ 1.35 fold change.