Table 3.

Changes in markers of fatty acid oxidation from baseline to three months

SUB PATHWAY	BIOCHEMICAL NAME	Fold of change, Month 3 vs. Baseline	p-value for paired t-test, Month 3 vs. Baseline	q-value for paired t-test, Month 3 vs. Baseline
Carnitine metabolism	deoxycarnitine	0.89	0.023	0.107
	carnitine	1.01	0.799	0.512
	3-dehydrocarnitine*	0.93	0.266	0.356
	acetylcarnitine	0.80	< 0.001	0.011
	hexanoylcarnitine	0.80	0.002	0.026
	octanoylcarnitine	0.72	< 0.001	0.011
	decanoylcarnitine	0.71	< 0.001	0.003
	laurylcarnitine	0.65	0.003	0.029
	palmitoylcarnitine	0.82	0.041	0.144
	stearoylcarnitine	0.77	0.004	0.035
	oleoylcarnitine	0.88	0.049	0.157
Ketone bodies	3-hydroxybutyrate (BHBA)	0.36	0.009	0.063
	acetoacetate	0.52	0.002	0.020
Fatty acid, dicarboxylate	2-hydroxyglutarate	0.96	0.728	0.508
	sebacate (decanedioate)	0.85	0.360	0.366
	dodecanedioate	0.80	0.016	0.092
	tetradecanedioate	0.72	0.105	0.237
	hexadecanedioate	0.67	0.053	0.168
	octadecanedioate	0.73	< 0.001	0.001
	3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF)	0.88	0.451	0.408

• All values are normalized in terms of raw area counts.

• “Fold change Month 3 vs. Baseline” denotes <month 3 level> divided by <baseline level> of each biochemical (i.e. fold change of 0.76 denotes a 24% decrease).

• Shading corresponds to degree of change. Thresholds for color intensity are as follows: green denotes ≤ 0.65 fold change, dark green denotes 0.65 - 0.95 fold change, black denotes 0.95 – 1.05 fold change, dark red denotes 1.05 – 1.35 fold change, red denotes ≥ 1.35 fold change.