Table 4.

Changes in biochemicals relevant to insulin resistance from baseline to three months

SUB PATHWAY	BIOCHEMICAL NAME	Fold of change, Month 3 vs. Baseline	p-value for paired t-test, Month 3 vs. Baseline	q-value for paired t-test, Month 3 vs. Baseline
	2-hydroxybutyrate (2-HB)	0.84	0.030	0.120
Valine, leucine and isoleucine metabolism	3-methyl-2-oxobutyrate	0.96	0.553	0.4393
	3-methyl-2-oxovalerate	0.99	0.548	0.4391
	beta-hydroxyisovalerate	0.94	0.203	0.3186
	isoleucine	0.91	0.066	0.1959
	leucine	0.93	0.118	0.2544
	valine	0.94	0.272	0.3558
	2-hydroxyisobutyrate	1.02	0.856	0.5260
	3-hydroxyisobutyrate	0.94	0.328	0.3558
	4-methyl-2-oxopentanoate	0.97	0.546	0.4386
	alpha-hydroxyisovalerate	0.91	0.016	0.0915
	isobutyrylcarnitine	1.01	0.802	0.5115
	2-methylbutyroylcarnitine	0.88	0.039	0.1414
	isovalerylcarnitine	0.99	0.475	0.4135
	hydroxyisovaleroyl carnitine	0.97	0.797	0.5115
	tiglyl carnitine	0.98	0.839	0.5222
	methylglutaroylcarnitine	0.86	0.072	0.2018

• All values are normalized in terms of raw area counts.

• “Fold change Month 3 vs. Baseline” denotes <month 3 level> divided by <baseline level> of each biochemical (i.e. fold change of 0.76 denotes a 24% decrease).

• Shading corresponds to degree of change. Thresholds for color intensity are as follows: green denotes ≤ 0.65 fold change, dark green denotes 0.65 - 0.95 fold change, black denotes 0.95 – 1.05 fold change, dark red denotes 1.05 – 1.35 fold change, red denotes ≥ 1.35 fold change.