TABLE 1.
Clinical Characteristics and Cerebrospinal Fluid Parameters of Study Series
| Characteristic | Discovery Series, n = 229 | First Replication Series, n = 256 | Second Replication Series, n = 153 |
|---|---|---|---|
| Age, mean yr (range) | 35 (16–67) | 36 (15–71) | 41 (14–71) |
| Gender, F:M | 173:56 | 172:84 | 106:47 |
| PPMS, No. [%] | 11 [4.8] | 5 [2.0] | 27 [17.6] |
| IgG index,a geometric mean (range) | 0.95 (0.29–3.94) | 0.85 (0.37–5.20) | 0.99 (0.43–5.36) |
Clinical characteristics and IgG index of the discovery series, and the first and second replication series. Patients who were excluded after quality control are not shown. Age is given for the time of lumbar puncture.
a
In this table, the original data of the IgG index are shown to illustrate results; for linear regression analysis, the natural logarithm of the IgG index was used.
F = female; IgG = gamma globulin; M = male; PPMS = primary progressive multiple sclerosis.