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Central leptin signaling via hypothalamic leptin receptors (LEPR) and sympathetic nervous system (SNS) to osteoblast b-adrenergic (Ob b-adr) receptors decreases trabecular bone volume (BV/TV). Peripheral leptin reportedly increases cortical bone growth and bone marrow stromal cell (BMSC) differentiation to osteoblast (Ob) vs. adipocyte (Adip) lineage.
