Table 2.

Acute Changes in Ovarian Reserve

Measure of Ovarian Reserve (N=46)	Baseline Levels Median (interquartile range)	Unadjusted Median Change During Treatment	Unadjusted Percent Change During Treatment n (95%CI)	P value	Adjusted Percent Change During Treatment* n (95% CI)	P value
FSH**	5.2 mIU/ml (3.3–8.6)	13.8 mIU/mL	321 (167 to 565)	<0.0001
Treatment < 90 days		5.0 mlU/mL	96 (−11 to 332)	0.088	37 (−90 to 1765)	0.27
Treatment ≥ 90 days		29.8 mIU/mL	554 (225 to 1216)	<0.0001	1544 (300 to 5779)	0.001
LH	4.0 mIU/mL (2.0–7.3)	5.2 mIU/mL	183 (69 to 373)	<0.0001	315 (46 to 1080)	0.009
AMH	2.0 ng/mL (1.0–3.5)	−1.7 ng/mL	−89 (−84 to −93)	<0.0001	−61 (−82 to −6)	0.018
Estradiol	41.0 pg/mL (25.3–61.8)	−27.2 pg/mL	−56 (−31 to −71)	.001	−25 (−69 to 81)	0.64
Inhibin	39.7 pg/mL (14.1–84.6)	−19.0 pg/mL	−55 (−25 to −73)	.003	37 (−46 to 247)	0.5
MOV (n=26)	9.8 cm3 (6.4–13.7)	−4.0 cm3	−46 (−28 to −60)	<0.0001	−18 (−55 to 49)	0.48
AFC (n=26)	20 follicles (11−41)	−27 follicles	−75 (−56 to −85)	<0.0001	24 (−57 to 258)	0.67

^*Models adjusted for hormone levels at baseline and alkylator score. FSH and Estradiol also adjusted for exogenous hormone use

^**Overall adjusted change in FSH not reported due to presence of interaction with treatment length