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. 2013 Apr 17;33(16):6990–7002. doi: 10.1523/JNEUROSCI.4998-12.2013

Figure 3.

Figure 3.

Behavioral characterization reveals no gross phenotypic alterations in adult male mice after loss of eEF2 kinase. A, Analysis of locomotion over a 2 h period reveals no significant difference in locomotor activity between wild-type (WT) littermates and eEF2K knock-outs (KOs) (n = 8–10/group) measured either in 5 min increments or in the amount of total activity over a 2 h test period (inset). B, Open-field analysis demonstrates no alterations in anxiety-related behavior between WT littermate controls and eEF2K KOs (n = 8–10/group) in time spent in the center or periphery of the arena. C, Elevated plus maze activity shows equivalent behavior between WT littermates and eEF2 kinase KOs (n = 8–10/group) in exploration of the closed arm and the open arm. D, Activity in a light/dark chamber shows that WT littermates and eEF2K KOs (n = 8–10/group) display comparable movement in each chamber. E, In an interaction chamber, control littermates and eEF2 kinase KOs (n = 8–10/group) show no significant differences in time spent with an empty cage or with a social target.