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. 2013 Apr 17;33(16):6990–7002. doi: 10.1523/JNEUROSCI.4998-12.2013

Figure 8.

Figure 8.

The acute antidepressant-like effects of ketamine is not manifested in GluA2 knock-out (KO) mice. A, The acute antidepressant-like effects of ketamine were examined at 30 min after intraperitoneal injection of either vehicle or ketamine (5.0 mg/kg) in wild-type (WT) and GluA2 KO mice using the forced swim test. Immobility in forced swim test is presented. Ketamine induces significantly less immobility in WT mice (ANOVA, F(3,19) = 18.88, p < 0.0001; Tukey's post hoc, p < 0.005; n = 9–10/group). Ketamine does not alter immobility in the GluA2 KO mice. B, C, WT and GluA2 KO animals were administered ketamine (5.0 mg/kg) or vehicle intraperitoneally. B, In novelty suppressed feeding (NSF) test 30 min after drug application, ketamine-treated WT mice show significantly decreased latency to feed (ANOVA, F(3,23) = 3.439, p = 0.0365; with Tukey's post hoc test, p < 0.05), whereas ketamine-treated GluA2 KO animals show no change in latency to acquire food. C, Post-test for the 30 min NSF test demonstrating that all groups show comparable appetite.