Table 3.
Change in Ejection Fraction Over Time: HFrEF
| Estimated Mean EF at HF Diagnosis (95% CI) | Estimated Change in EF Over 5 years (95% CI) | |
|---|---|---|
| Overall (n=674) | 31.7 (30.9, 32.5) | 6.9 (5.4, 8.4) |
| p<0.001 | ||
| Men | ||
| < 70 (n=142) | 29.0 (27.4, 30.6) | 6.5 (4.2, 8.8) |
| 70–79 (n=128) | 30.9 (29.1, 32.6) | 4.5 (1.8, 7.1) |
| ≥ 80 (n=117) | 32.2 (30.2, 34.1) | 1.8 (−2.3, 5.9) |
| * p=0.0015 | * p=0.006 | |
| Women | ||
| < 70 (n=68) | 34.1 (31.8, 36.4) | 10.9 (8.2, 13.5) |
| 70–79 (n=89) | 33.1 (31.1, 35.2) | 8.8 (6.1, 11.6) |
| ≥ 80 (n=130) | 33.2 (31.4, 35.0) | 6.2 (2.1, 10.3) |
| * p=0.002 | * p=0.006 | |
| Coronary artery disease | ||
| No (n=441) | 31.5 (30.5, 32.5) | 9.4 (7.7, 11.1) |
| Yes (n=233) | 32.2 (30.9, 33.0) | 0.3 (−2.5, 3.1) |
| * p=0.42 | * p=0.02 | |
| LVEDD | ||
| < Median (57mm) (n=210) | 36.8 (35.5, 38.1) | 7.6 (4.8, 10.4) |
| ≥ Median (n=230) | 28.8 (27.5, 30.0) | 7.1 (4.6, 9.6) |
| * p<0.001 | * p= 0.93 | |
| Medication Use at Baseline | ||
| None (n=197) | 31.9 (30.4, 33.4) | 4.0 (1.2, 6.9) |
| Beta blocker, ACE-I, ARB (n=477) | 31.6 (30.7, 32.5) | 7.8 (6.1, 9.5) |
| * p=0.71 | * p=0.02 | |
CI=confidence interval,
*
p indicates significance of difference in EF or change in EF according to indicated variables