TABLE 2.
Specific Phenotypes of Macrophages (MΦs) in Different Tissues.
| Organ | Location and types | Markers |
|---|---|---|
| Liver (266–268) | Sinusoids Kupffer cells | F4/80highCD11blowCD169+ CD68+Mac-2+ |
| Spleen (269–273) | Red pulp MΦs | F4/80high CD11blow CD169low MHCIIlowD163+CD68+CD115+CD172a+ |
| Marginal zone MΦs | F4/80−SIGN-R1+MARCO+ | |
| Marginal zone Metalophilic MΦs, | F4/80−CD169+ | |
| Tingible body MΦs | F4/80−CD11b−CD68+MFG-E8+ | |
| Lung (267, 274–278) | Alveolar MΦs | F4/80+CD11blowCD169+CD11chighCD68+SiglecF+ MARCO+Mac-2+ |
| Alveolar interstitialMΦs | CD11c−F480+CD68+MHCII+ | |
| Lymph Node (279, 280) | Subcapsular sinus MΦs | F4/80lowCD11b+CD169+CD11low |
| Medullary MΦs | F4/80high CD11b+CD169+CD11clow | |
| Boundary between the sinus and the T cell zone | CD11chighCD169+MΦ | |
| B cell follicle MΦs | MHCII+F4/80+CD169+CD11chighCD8+ | |
| Germinal centertingible body MΦs | F4/80−CD11b−CD68+MFG-E8+ | |
| Gut (281, 282) | Lamina propria MΦs, | MHCII+F4/80+CD11b+CD11c+CD103−CD115+CX3CR1+CD172a+ |
| Muscular layer and serosa MΦs | MHCIIhighF4/80+CD11b+CD169+CD11clowCX3CR1+CD103−CD115+ | |
| Bone (283–285) | Bone marrow MΦs | CD169+F4/80+CD11blowCD169+CD11clowCD68+CX3CR1−CD115+ |
| Pro-osteoclasts | CD11b−F4/80 | |
| Pre-osteoclasts | CD11b−F4/80lowlow | |
| Mature osteoclasts | CD11b+F4/80medium | |
| Thymus (286) | Germinal center subcapsular MΦs, | MHCII+F4/80+Mac-2−FcγRII+FcγRIII+ |
| Germinal center cortex MΦs | MHCII−F4/80+Mac-2+FcγRII+FcγRIII+ | |
| Germinal center cortico-medullaryMΦs, | MHCII+F4/80+Mac-2+ FcγRIIhighFcγRIIIhigh | |
| Germinal center medullar MΦs | MHCIIhighF4/80+Mac-2+ FcγRII+FcγRIII+ | |
| Skin (287, 288) | Dermal MΦs | F4/80+CD11b+CD11clowmMGL+CD206+MHCIIlowCD169+ |
| Peritoneal lavage (289) | Peritoneal MΦs | CD11bhigh F4/80high CD11c− |
| Brain (290) | Microglial cells | CD11b+CD14+CSFR1+CX3CR1+CD172+CD200+CD45+ |