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Plasma pharmacokinetic parameters of LACV and the regenerated ACV following oral administration of LACV in rats. (Values are represented as mean ± S.D, n = 3–4).
| pK parameter | LACV | ACV |
|---|---|---|
| Cmax (μM) | 3.38 ± 0.13 | 26.5 ± 4.15 |
| Tmax (min) | 13.7 ± 2.5 | 15 |
| Clast (μM) | 0.16 ± 0.04 | 0.016 ± 0.007 |
| AUC0-t (min*μM) | 86.3 ± 22.4 | 958.9 ± 106.9 |
| AUC0-inf (min*μM) | 91.2 ± 21.06 | 959.8 ± 107.4 |
