Table 4.
Plasma pharmacokinetic parameters of LDACV and the generated DACV and ACV following i.v. administration of LDACV in rats. (Values are represented as mean ± S.D, n = 3–4).
| pK parameter | LDACV | DACV | ACV |
|---|---|---|---|
| λz (min−1) | 0.277 ± 0.051 | 0.044 ± 0.004 | 0.046 ± 0.008 |
| C0 (μM) | 111.8 ± 47.1 | 1.36 ± 0.22 | 1.82 ± 0.39 |
| Tlast (min) | 15 | 30 | 33.75 ± 7.5 |
| Clast (μM) | 1.44 ± 0.73 | 0.2 ± 0.05 | 0.24 ± 0.14 |
| AUC0–t (min*μM) | 411.1 ± 109.9 | 15.4 ± 1.35 | 22.74 ± 2.80 |
| AUC0–inf (min*μM) | 416.8 ± 106.7 | 20.2 ± 3.04 | 29.4 ± 6.28 |
| Vz (L/kg) | 0.21 ± 0.099 | 25.1 ± 1.98 | 18.2 ± 2.65 |
| Cl (L/min/kg) | 0.055 ± 0.014 | 1.12 ± 0.18 | 0.77 ± 0.149 |