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Comparison of pharmacokinetic parameters of intact prodrug (dipeptide + amino acid metabolite) obtained following oral delivery of LACV and LDACV. (Each value represents mean ± SD, n = 3–4).
| pK parameter | LACV | LDACV |
|---|---|---|
| Cmax (μM) | 3.37 ± 0.13 | 15.06 ± 2.68 |
| Tmax (min) | 15 | 15 |
| AUC0-inf (Min*μM) | 91.2 ± 21.06 | 336.6 ± 20.09 |
