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. 2013 Apr 30;8:105. doi: 10.1186/1748-717X-8-105

Figure 1.

Figure 1

Non-cytotoxic concentration of patupilone counteracts IR-enhanced MMP activity. A, MMP activity was determined in the CM derived from HT1080 cells treated with 0.2 nM patupilone and indicated doses of IR. Cells were pretreated with or without patupilone for 24 h and sham-treated or irradiated with the indicated doses of IR. The cell culture media was discarded 1 h after irradiation and cells were incubated for additional 24 h in serum-free medium to obtain CM, n = 13. B, clonogenic cell survival of HT1080 cells was determined after treatment with increasing doses of patupilone and IR, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001.