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IR-induced cell invasiveness is inhibited by patupilone and is dependent on TIMP protein level. Invasiveness of the HT1080 cells was assessed in the Transwell invasion assay after treatment with patupilone (0.2 nM) and 2 Gy IR, n > 3 (A) as indicated in detail in the method section. B, HT1080 cells were transfected with siLuc, siTIMP-1 and siTIMP-2 prior to treatment with patupilone and IR, n = 5, followed by the invasion assay. *P < 0.05, **P < 0.01, ***P < 0.001.
