Table 4.

Comparison of serum lipid and PCSK9 concentrations in non-carriers versus carriers of a given PCSK9 variant values

PCSK9 Genotype	Total Cholesterol (mmol/L)	p-value	Triglyceride (mmol/L)	p-value	HDL Cholesterol (mmol/L)	p-value	LDL Cholesterol (mmol/L)	p-value	Serum PCSK9 (ng/mL)	p-value
Non-Carrier (n = 155)	5.67 ± 1.16		1.54 ± 0.73		1.19 ± 0.35		3.78 ± 1.00		327.2 ± 130.6
L10A53V		0.0047		0.56		0.63		0.0002		0.76
Carrier (n = 52)	5.13 ± 0.99		1.66 ± 0.82		1.21 ± 0.49		3.17 ± 0.92		326.5 ± 133.0
Non-Carrier (n = 150)	5.59 ± 1.19		1.54 ± 0.75		1.19 ± 0.37		3.70 ± 1.06		338.6 ± 136.2
I474V		0.13		0.57		0.86		0.056		0.033
Carrier (n = 57)	5.35 ± 0.98		1.61 ± 0.76		1.21 ± 0.44		3.42 ± 0.86		296.7 ± 111.0
Non-Carrier (n = 192)	5.56 ± 1.14		1.59 ± 0.77		1.20 ± 0.40		3.64 ± 1.01		328.1 ± 127.0
E670G		0.19		0.13		0.36		0.59		0.44
Non-Carrier (n = 15)	5.11 ± 1.12		1.27 ± 0.48		1.10 ± 0.30		3.45 ± 1.11		313.8 ± 177.9

Variant values represent mean ± SD. Differences between groups were determined by Mann Whitney test with level of significance as p < 0.05.