Table 5.
Comparison of serum lipid and PCSK9 concentrations in non-carriers of any PCSK9 variant versus carriers of only a given PCSK9 variant values
| PCSK9 Genotype | Total Cholesterol (mmol/L) | p-value | Triglyceride (mmol/L) | p-value | HDL Cholesterol (mmol/L) | p-value | LDL Cholesterol (mmol/L) | p-value | Serum PCSK9 (ng/mL) | p-value |
|---|---|---|---|---|---|---|---|---|---|---|
|
No Variant (n = 101) |
5.82 ± 1.15 |
|
1.55 ± 0.72 |
|
1.19 ± 0.34 |
|
3.93 ± 0.97 |
|
341.0 ± 128.9 |
|
|
L10A53V |
|
0.0032 |
|
0.82 |
|
0.64 |
|
0.0005 |
|
0.84 |
|
Only (n = 29) |
5.09 ± 0.96 |
|
1.67 ± 0.86 |
|
1.18 ± 0.41 |
|
3.15 ± 0.96 |
|
352.7 ± 138.5 |
|
|
No Variant (n = 101) |
5.82 ± 1.15 |
|
1.55 ± 0.72 |
|
1.19 ± 0.34 |
|
3.93 ± 0.97 |
|
341.0 ± 128.9 |
|
|
I474V |
|
0.097 |
|
0.53 |
|
0.86 |
|
0.050 |
|
0.087 |
|
Only (n = 37) |
5.48 ± 1.01 |
|
1.67 ± 0.81 |
|
1.18 ± 0.39 |
|
3.54 ± 0.90 |
|
301.3 ± 110.2 |
|
|
No Variant (n = 101) |
5.82 ± 1.15 |
|
1.55 ± 0.72 |
|
1.19 ± 0.34 |
|
3.93 ± 0.97 |
|
341.0 ± 128.9 |
|
|
E670G |
|
0.043 |
|
0.039 |
|
0.69 |
|
0.14 |
|
0.34 |
| Only (n = 9) | 4.88 ± 1.01 | 1.12 ± 0.41 | 1.14 ± 0.37 | 3.24 ± 1.08 | 329.3 ± 227.8 |
Variant values represent mean ± SD. Differences between groups were determined by Mann Whitney test with level of significance as p < 0.05.