Table 3.
Regional gray matter changes (Pcrit < .001, k = 1,400)
| MNI coordinates (x y z) | Cluster extent (k) | Cluster-level Pcorrected | Voxel-level PFWE-corrected | T | Region description (for cluster peak) |
|---|---|---|---|---|---|
| Between-group analyses | |||||
| Interaction control > CTx+ from baseline to M1 | |||||
| –41 40 –7 | 2,204 | .008 | .01 | 5.36 | L middle frontal gyrus (BA47) |
| –35 –63 –49 | 7,732 | <.001 | NS | 4.85 | L cerebellum |
| 26 52 –11 | 1,952 | .014 | NS | 4.62 | R middle frontal gyrus (BA11) |
| Interaction control > CTx+ from baseline to Y1 | |||||
| 8 –80 –43 | 3,514 | .001 | NS | 4.33 | R cerebellum |
| –39 –53 –50 | 1,611 | .032 | NS | 4.15 | L cerebellum |
| Interaction control > CTx– from baseline to M1 | |||||
| 16 –75 –37 | 2,050 | .011 | NS | 4.48 | R cerebellum |
| Within-group (CTx+) analyses | |||||
| Gray matter decline from baseline to M1 | |||||
| –44 39 –6 | 5,600 | <.001 | <.001 | 6.23 | L middle frontal gyrus (BA47) |
| 14 30 54 | 6,063 | <.001 | .011 | 5.34 | R superior frontal gyrus (BA8) |
| 52 –2 39 | 2,823 | .002 | .023 | 5.14 | R precentral gyrus (BA6) |
| 12 56 –16 | 3,895 | <.001 | .053 | 4.92 | R superior frontal gyrus (BA11) |
| –37 –71 –33 | 4,915 | <.001 | NS | 4.74 | L cerebellum |
| –23 –23 –10 | 1,744 | .023 | NS | 4.52 | L parahippocampal gyrus (BA28) |
| –15 49 36 | 2,734 | .003 | NS | 4.45 | L superior frontal gyrus (BA9) |
| 34 6 –45 | 2,568 | .004 | NS | 4.35 | R superior temporal gyrus (BA38) |
| 24 –30 2 | 2,883 | .002 | NS | 4.31 | R thalamus |
| 38 –74 –29 | 1,486 | .043 | NS | 3.94 | R cerebellum |
| Gray matter decline from baseline to M1 with recovery at Y1 | |||||
| –42 39 –7 | 2,903 | .002 | .011 | 5.33 | L middle frontal gyrus (BA47) |
| 14 30 54 | 3,443 | .001 | .028 | 5.09 | R superior frontal gyrus (BA8) |
| –12 49 37 | 1,753 | .022 | NS | 4.76 | L superior frontal gyrus (BA9) |
| 33 9 –49 | 1,592 | .033 | NS | 4.36 | R superior temporal gyrus (BA38) |
| 32 57 –4 | 1,906 | .016 | NS | 4.35 | R superior frontal gyrus (BA10) |
| 9 –53 –27 | 1,537 | .038 | NS | 4.23 | R cerebellum |
| Gray matter decline from baseline to M1 persisting at Y1 | |||||
| –44 39 –6 | 2,025 | .012 | .010 | 5.36 | L middle frontal gyrus (BA47) |
| 24 –30 2 | 2,776 | .002 | .025 | 5.12 | R thalamus |
| 16 17 59 | 2,460 | .005 | .030 | 5.07 | R superior frontal gyrus (BA6) |
| –38 –58 –48 | 8,184 | <.001 | .035 | 5.03 | L cerebellum |
| 10 –78 –41 | 6,352 | <.001 | NS | 4.86 | R cerebellum |
| 8 57 –17 | 1,836 | .018 | NS | 4.78 | R medial frontal gyrus (BA11) |
| 35 –13 51 | 2,550 | .004 | NS | 4.77 | R precentral gyrus (BA6) |
| –33 29 41 | 1,849 | .018 | NS | 4.16 | L middle frontal gyrus (BA9) |