Table 2. Association with Colon Cancer of SNPs Selected for Replication in the Discovery Sample (Phase 1).
| Cases (N = 464) | Controls (N = 393) | OR (95% CI)† | p † | |
| rs1365611 | <0.0001 | |||
| CC | 176 (48.0) | 165 (38.9) | 4.97 (2.73–9.05) | |
| CT | 174 (47.4) | 188 (44.3) | 4.59 (2.52–8.33) | |
| TT | 17 (4.6) | 71 (16.8) | 1.0 (ref) | |
| rs2253442 | 0.55 | |||
| GG | 204 (56.4) | 231 (52.6) | 1.29 (0.71–2.34) | |
| AG | 135 (37.3) | 175 (39.9) | 1.13 (0.61–2.07) | |
| AA | 23 (6.4) | 33 (7.5) | 1.0 (ref) | |
| rs2555639 | 0.038 | |||
| TT | 180 (46.5) | 172 (37.5) | 1.71 (1.09–2.69) | |
| CT | 163 (42.1) | 213 (46.4) | 1.28 (0.82–2.01) | |
| CC | 44 (11.4) | 74 (16.1) | 1.0 (ref) | |
| rs2555642 | 0.53 | |||
| TT | 219 (57.1) | 245 (54.1) | 1.38 (0.75–2.53) | |
| CT | 144 (37.5) | 176 (38.9) | 1.24 (0.66–2.31) | |
| CC | 21 (5.5) | 32 (7.1) | 1.0 (ref) | |
| rs2555622 | 0.18 | |||
| AA | 158 (42.9) | 216 (48.8) | 1.0 (ref) | |
| AC | 171 (46.5) | 186 (42.0) | 0.99 (0.59–1.64) | |
| CC | 39 (10.6) | 41 (9.3) | 1.31 (0.79–2.17) | |
| rs6844282 | <0.0001 | |||
| CC | 132 (34.4) | 122 (26.9) | 2.38 (1.55–3.67) | |
| CG | 198 (51.6) | 211 (46.6) | 2.31 (1.55–3.45) | |
| GG | 54 (14.1) | 120 (26.5) | 1.0 (ref) | |
| rs11724251 | 0.053 | |||
| AA | 114 (30.0) | 171 (37.5) | 1.0 (ref) | |
| AG | 197 (51.8) | 208 (45.6) | 1.01 (0.68–1.51) | |
| GG | 69 (18.2) | 77 (16.9) | 1.47 (0.96–2.26) | |
| rs10019035 | 0.065 | |||
| CC | 317 (83.0) | 374 (82.2) | 1.0 (ref) | |
| CT | 64 (16.8) | 71 (15.6) | 11.9 (1.46–97.5) | |
| TT | 1 (0.3) | 10 (2.2) | 11.9 (1.49–94.6) | |
| rs2332897 | <0.0001 | |||
| CC | 181 (47.0) | 175 (38.8) | 4.59 (2.60–8.11) | |
| CA | 185 (48.1) | 198 (43.9) | 4.46 (2.53–7.87) | |
| AA | 19 (4.9) | 78 (17.3) | 1.0 (ref) |
†
Odds ratio (OR) for colon cancer risk and 95% confidence interval (CI) for having one or two risk alleles, compared to having no risk alleles, and the additive model p-value from logistic regression adjusting for age and gender, but not adjusted for multiple testing.