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. 2013 May 22;8(5):e64096. doi: 10.1371/journal.pone.0064096

Figure 1. Cytoplasmic N-terminal domain of a GIRK5 subunit and constructs generated.

Figure 1

A) GIRK5 is composed of a short intracellular N-terminus, two trans-membrane helices (M1 and M2), a pore (P), an extracellular loop, and a long unstructured C-terminus (Bichet D., 2003 and Choe S., 2002). The N-terminus of GIRK5 contains an acidic di-leucine motif (16-YEXXXLI-22) that drives its cellular trafficking. B) Name and description of each mutant used in this study.