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. 2013 May 22;8(5):e64829. doi: 10.1371/journal.pone.0064829

Table 4. Genes down-regulated after in vitro treatment of human endometrium stromal cells.

Gene p-value hCG/IL1 FC hCG/IL1 p-value MM/IL1 FC MM/IL1 p-value hCG/MM FC hCG/MM IPA Pf. IPA Im. IPA Rm. IPA CS. IPA Ap. IPA Ag.
ETV1 0.02017 −5.26
HSD17B2 0.03976 −5.06
LOXL4 0.00528 −4.74 0.00435 −5.01
CDK1 0.03192 −4.25 X X
ITGA6 0.00651 −3.82 0.01105 −3.35 X X X
DUSP6 0.00051 −3.56 0.01223 −2.08 X X
SLC20A1 0.00306 −3.08 X
POLE2 0.00645 −2.86 0.01939 −2.31
CCNA2 0.02166 −2.66 X X X
MCM6 0.00275 −2.54
KRT19á 0.00000 −2.50 0.00001 −2.26
RFC3 0.00785 −2.49
KRT34 0.00247 −2.45
E2F7 0.04905 −2.38 X
BRCA1 0.01466 −2.25 0.02641 −2.04 X X
PAK1 0.00399 −2.24 0.02263 −1.77 X X X X
HELLS 0.04234 −2.22 X
ANGPTL4 0.01955 −2.09 X X
ITGA4 0.00435 −2.03 0.00371 −2.08 X X X X
ACTA2 0.01071 −1.91 0.02904 −1.68 X
CCND1 0.00041 −1.90 X X X
HOXA11 0.00279 −1.88 0.00047 −2.31
ITGA3 0.00146 −1.69 X X X
FZD1 0.00697 −1.58 0.00048 −2.06 X
POLA2 0.02091 −1.51 0.00795 −1.66
ITGB5 0.03518 −1.53 X X X X
ANXA4 0.02022 −1.53 X
TIMP3áâ 0.01839 −1.57 X X X X
BCL2L10 0.00814 −1.58 X
SMAD9 0.01991 −1.61
IGF2BP3 0.02094 −1.62 X
C5 0.01257 −1.68 X X X X X
TGFBR3 0.04598 −1.82 X X X X
ANGPTL2 0.02817 −1.84
FAS 0.03925 −1.85 X X X X X
LAMB1 0.03736 −1.91 X X
TNFRSF19 0.02307 −2.26 X
PDGFD 0.01484 −3.19 X X
MMP10á 0.01030 −3.91 X
IL13RA2 0.04783 −3.64 X
CCNE2 0.01264 −2.78 X X
PLAU 0.00713 −2.42 X X X X
MELK 0.01473 −2.41
ITGA2 0.01329 −2.37 X X X X
CDC45 0.01108 −2.30 X X
SPAG5 0.03517 −2.16 ?
BRCA2 0.03864 −1.96 X X X
E2F8 0.02061 −1.85 X
MMP3 0.02542 −1.84 X X X
MCM5 0.01884 −1.79
MCM3 0.02412 −1.62
ORC1 0.00293 −1.60
PCNA 0.02189 −1.59 X X
E2F1 0.00984 −1.55 X X X X
IL1Aá 0.02429 −1.52 X X X X X X
FOSL1 0.01092 −1.50 X X X
á/â

Real-time PCR/ ELISA validation performed

Pf, proliferation; Im, immune functions; Rm, tissue remodeling; CS, cell signaling; Ap, apoptosis; Ag, angiogenesis