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. 2013 May 22;8(5):e63643. doi: 10.1371/journal.pone.0063643

Figure 8. Neurochemical profile of the hippocampus measured by single voxel 1H MRS at 7 Tesla.

Figure 8

A: Representative 1H MR spectra acquired from the hippocampus of a 12-month-old wild-type mouse. B: Representative 1H MR spectra acquired from the hippocampus of a 12-month-old AβPPswe-PS1dE9 transgenic mouse. Notice the decreased NAA peak in AβPP-PS1compared to wild-type. C: At 8 months of age, no differences between wild-type (n = 13) and AβPP-PS1 mice (n = 8) were observed in the hippocampal neurochemical profile. D: At 12 months of age, AβPP-PS1 mice (n = 4) had significantly lower concentrations of NAA than wild-type mice (n = 7), *p<0.05. tCho = choline-containing compounds; tCre = creatine and phosphocreatine; Glu = glutamate; Glx = glutamine and glutamate; mI+Gly = myo-Inositol and glycine; NAA = N-acetylaspartate; Tau = taurine.