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. 2013 May 17;62(6):1981–1989. doi: 10.2337/db11-1740

FIG. 3.

FIG. 3.

The effect of obesity on diurnal variation in response to glucose and insulin challenge at 8:00 a.m. and 8:00 p.m. A: Glucose tolerance test; diurnal response to intraperitoneal glucose challenge in obese and lean animals. B: Glucose tolerance test; diurnal variation in glucose peak at 30 min is blunted in obesity. C: Insulin tolerance test; diurnal response to intraperitoneal insulin challenge in obese and lean animals. D: Insulin tolerance test; diurnal variation in glucose nadir at 60 min is blunted in obesity. A and C: Results from obese animals are denoted by circles and lean by triangles and values at 8:00 a.m. by open symbols and those at 8:00 p.m. by closed symbols. B and D: Obese animals are denoted by checkered bars and lean by solid bars. Student t test: *P < 0.05 and †P < 0.01; n = 16 in each group.