FIG. 3.

Chronic, but not acute, treatment of PEGPH20 increases insulin sensitivity in DIO mice. DIO mice received one (acute) or multiple (chronic) intravenous injections of vehicle or PEGPH20. IC_v was performed 3 days after the injection to determine blood glucose (A and E); GIR (B and F); Rg (C and G), an index of muscle glucose uptake; and endogenous glucose production (EndoRa) and glucose disappearance rate (Rd) (D and H). n = 4–8. *P < 0.05 vs. vehicle. All data are represented as mean ± SEM.