FIG. 1.

Ptger3 expression and PGE₂ production are increased in a mouse model of T2D but not a mouse model of obesity. A: Islet RNA samples from 4- or 10-week-old BTBR-lean (lean) or diabetic BTBR-Ob (obese) (5 mice per group) were subjected to microarray analysis using Agilent custom ink-jet microarrays as previously described (7). Ptger3 intensity was significantly increased in islets from diabetic BTBR-Ob mice compared with all other groups. B: Body weights of the mice used to generate the islet gene expression data in A at the time of islet isolation showing equivalent percent increases in body mass between the B6 and BTBR groups. wks, week.